Gastroesophageal Reflux Disease Is Associated With the C825T Polymorphism in the G-Protein β3 Subunit Gene (GNB3)

Abstract

GERD is associated with GNB3 C825T. The results for GERD subgroups support the hypothesis that enhanced perception of reflux events, as a consequence of the increased signal transduction upon GPCR activation associated with the 825T allele, underlies this association.