POWSIM: a computer program for assessing statistical power when testing for genetic differentiation

Nils Ryman, Stefan Palm

Molecular Ecology Notes · 2006 · 646 citations · 10 references

Concepts

TL;DR

Statistical power is essential for sampling design and data evaluation in tests of genetic differentiation, but such information is often missing in conservation and evolutionary genetics studies due to complex interacting factors. powsim is a Windows/DOS simulation program that estimates power and type‑I error for chi‑square and Fisher's exact tests of genetic homogeneity, allowing users to specify sample size, number of loci, allele frequencies, and F_ST, and is available at http://www.zoologi.su.se/~ryman.

Abstract

Abstract Knowledge of statistical power is essential for sampling design and data evaluation when testing for genetic differentiation. Yet, such information is typically missing in studies of conservation and evolutionary genetics, most likely because of complex interactions between the many factors that affect power. powsim is a 32‐bit Windows/DOS simulation‐based computer program that estimates power (and α error) for chi‐square and Fisher's exact tests when evaluating the hypothesis of genetic homogeneity. Optional combinations include the number of samples, sample sizes, number of loci and alleles, allele frequencies, and degree of differentiation (quantified as F ST ). powsim is available at http://www.zoologi.su.se/~ryman .

References

10