GENERALIZED CAPILLARY AND ARTERIOLAR THROMBOSIS

Abstract

Article1 December 1939GENERALIZED CAPILLARY AND ARTERIOLAR THROMBOSISREPORT OF TWO CASES WITH A DISCUSSION OF THE LITERATURE*SAMUEL GITLOW, M.D., CARL GOLDMARK, M.D.SAMUEL GITLOW, M.D.Search for more papers by this author, CARL GOLDMARK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-6-1046 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThese two cases are being reported together because they show similar pathologic changes even though clinically they differ entirely. The pathologic process is characterized by generalized arteriolar and capillary thrombosis.While we realize that atypical verrucous endocarditis with a skin lesion resembling lupus erythematosus was described by Libman and Sacks1in 1923, and that Moschcowitz2the following year presented a case before the N. Y. Pathological Society under the title of "Hyaline Thrombosis of the Terminal Arterioles and Capillaries (A Hitherto Undescribed Disease)," we feel that despite the fact of the description of these two widely differing clinical conditions, the...References1. LIBMAN E: Some general considerations concerning affections of the valves of the heart, Med. Clin. North Am., 1917, i, 573-590. LIBMAN, EMANUEL, and SACKS, BENJAMIN: A hitherto undescribed form of valvular and mural endocarditis, Trans. Assoc. Am. Phys., 1923, xxxviii, 46-61. Abstract—Jr. Am. Med. Assoc., 1923, lxxx, 1724. LIBMAN, EMANUEL, and SACKS, BENJAMIN: Atypical verrucous endocarditis, Proc. New York Path. Soc., 1923, xxiii, 69-74. LIBMAN, EMANUEL, and SACKS, BENJAMIN: A hitherto undescribed form of valvular and mural endocarditis, Arch. Int. Med., 1924, xxxiii, 701-737. Google Scholar2. MOSCHCOWITZ E: Hyaline thrombosis of the terminal arterioles and capillaries: a hitherto undescribed disease, Proc. New York Path. Soc., 1924, xxiv, 21-24. MOSCHCOWITZ, ELI: An acute pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries, Arch. Int. Med., 1925, xxxvi, 89-93. Google Scholar3. DAVISAYONEN DD: Subacute bacterial endocarditis with unusual vesiculobullous skin lesions: necropsy reports of 2 cases, Am. Heart Jr., 1927, ii, 671-681. CrossrefGoogle Scholar4. ROXBURGH AC: Acute disseminated lupus erythematosus: 5 fatal cases, Brit. Jr. Dermat. and Syph., 1933, xlv, 95-109. CrossrefGoogle Scholar5. GROSS L: The heart in atypical verrucous endocarditis (Libman-Sacks), Libman's Anniversary Volume, 1932, ii, 527-550. Google Scholar6. LIBMAN E: Characterization of the various forms of endocarditis, Jr. Am. Med. Assoc., 1923, lxxx, 813-818. CrossrefGoogle Scholar7. KAPOSI (MORITZ KOHN): Neue Beiträge zur Kenntnis der Lupus Erythematosus, Arch. f. Dermat. u. Syph., 1872, iv, 36-78. CrossrefGoogle Scholar8. GOECKERMANMONTGOMERY WHH: Lupus Erythematosus. An evaluation of histopathological examinations, Arch. Dermat. and Syph., 1932, xxv, 304-316. CrossrefGoogle Scholar9. OSLER W: Malignant endocarditis (Goulstonian Lectures), Lancet, 1885, i, 415-418; 459-466; 505-508. CrossrefGoogle Scholar10. OSLER W: On the visceral manifestations of erythema exudativum multiforme, Am. Jr. Med. Sci., 1895, cx, 629-646. OSLER, SIR WILLIAM: The visceral lesions of the erythema group (2nd series of cases), Brit. Jr. Dermat., 1900, xii, 227-245. OSLER, SIR WILLIAM: On the visceral manifestations of the erythema group of skin diseases, Am. Jr. Med. Sci., 1904, cxxvii, 1-23. OSLER, SIR WILLIAM: The visceral lesions of purpura and allied conditions, Brit. Med. Jr., 1914, i, 517-525. CrossrefGoogle Scholar11. MACKENZIE S: Case of local asphyxia, acne neurotica and lupus erythematosus, Brit. Jr. Dermat., 1898, x, 10-11. Google Scholar12. GALLOWAY J: In report of meeting of Dermatological Soc. of London Med., Jan. 12, 1898. Brit. Jr. Dermat., 1898, x, 49-50. CAVAFY, JOHN: In report of meeting of same society March 9, 1898, p. 139-140. Google Scholar13. FORDYCE JA: Lupus erythematosus in a tuberculous subject, Jr. Cutan. and G. A. Dis., 1899, xvii, 113-116. Google Scholar14. FORDYCEHOLDER JAOH: Some clinical observations on lupus erythematosus; the pathology of lupus erythematosus, Med. Rec., 1900, lviii, 41-48. Google Scholar15. GALLOWAYMACLEOD JJM: Erythema multiforme and lupus erythematosus; their relationship to general toxemia, Brit. Jr. Dermat., 1903, xv, 81-94. CrossrefGoogle Scholar16. SCHMIDT W: Ueber drei Faelle von Lupus Erythematosus Acutus nebst statistischen Beiträgen zur Lehre dieser Krankheit und Besprechung der Aetiologie derselben, Dermat. Ztschr., 1914, xxi, 28-65. CrossrefGoogle Scholar17. CULVER GD: Lupus erythematosus of the mucous membranes, Jr. Am. Med. Assoc., 1915, lxv, 773-778. CrossrefGoogle Scholar18. CHRISTIAN HA: Long continued fever with inflammatory changes in serous and synovial membranes and eventual glomerulonephritis. A clinical syndrome of unknown etiology, Med. Clin. North Am., 1935, xix, 1023-1026. Google Scholar19. TRIMBLE IR: Erythematous group of skin diseases with especial reference to abdominal pain, Jr. Am. Med. Assoc., 1931, xcvi, 2010-2014. CrossrefGoogle Scholar20. JARCHO S: Lupus erythematosus associated with visceral vascular lesions, Bull. Johns Hopkins Hosp., 1936, lix, 262-274. Google Scholar21. RICKER G: Pathologie als Naturwissenschaft-Relations-pathologie, 1924, 42-52; 98; 188; 193. RICKER, GUSTAV: Die Methode der direkter Beobachtung der lokalen Kreislaufs Stoerungen und die Verwertung pathologisch-anatomische Befunden Kreislaufs Organen für die Pathologie derselben, Handb. d. biologischen Arbeitsmethoden, 1924, viii, Teil 1, Hefte 1. CrossrefGoogle Scholar22. MIDSUNO R: Beiträge zur Morphologie und Physiologie der terminalen Blutbahn, Beitr. z. Path. Anat., 1930, lxxxiv, 183-230. Google Scholar23. MALLORY : Cited by Flexner.24 Google Scholar24. FLEXNER S: On thrombi composed of agglutinated red blood cells, Jr. Med. Res. (n.s.), 1902, iii, 316-321. Google Scholar25. BOXMEYER CH: A study of the necroses occurring in the liver of experimental animals after inoculation with hog cholera bacilli, Jr. Med. Res. (n.s.), 1903, iv, 146-163. Google Scholar26. SCRIVEROERTEL WDH: Necrotic sequestration of the kidneys in pregnancy (symmetrical cortical necrosis), Jr. Path. and Bact., 1930, xxxiii, 1071-1094. CrossrefGoogle Scholar27. NEUBURGER K: Ueber angiospastische nichtembolische Enstehung von Niereninfarkten und von Extremitätengangrän, Virchow's Arch. f. path. Anat. u. Physiol., 1927, cclxv, 789-804. CrossrefGoogle Scholar28. SCHWARTZMANKLEMPERERGERBER GPIE: The phenomenon of local tissue reactivity to bacterial filtrates (the rôle of arteriolar vascular responses in certain human diseases), Jr. Am. Med. Assoc., 1936, cvii, 1946-1951. SCHWARTZMAN, GREGORY: Libman's Anniversary Volume, 1932. CrossrefGoogle Scholar29. GROSSFRIEDBERG LCK: Non-bacterial thrombotic endocarditis. Classification and general description, Arch. Int. Med., 1936, lviii, 620-640. FRIEDBERG, CHARLES K., and GROSS, LOUIS: Non-bacterial thrombotic endocarditis associated with acute thrombocytopenic purpura, Arch. Int. Med., 1936, lviii, 641-661. FRIEDBERG, CHARLES K., GROSS, LOUIS, and WALLECH, KAUFMAN: Non-bacterial thrombotic endocarditis associated with prolonged fever, inflammation of serous membranes, and widespread vascular lesions, Arch. Int. Med., 1936, lviii, 662-684. CrossrefGoogle Scholar30. FRIEDBERGGROSS CKL: Periarteritis nodosa (necrotizing arteritis) associated with rheumatic heart disease (with a note on abdominal rheumatism), Arch. Int. Med., 1934, liv, 170-198. CrossrefGoogle Scholar31. BAEHR G: The renal complications of endocarditis, Trans. Assoc. Am. Phys., 1931, xlvi, 87-95. BAEHR, GEORGE, KLEMPERER, PAUL, and SCHIFRIN, ARTHUR: A diffuse disease of the peripheral circulation (usually associated with lupus erythematosus and endocarditis), Trans. Assoc. Am. Phys., 1935, l, 139-155. Google Scholar32. SPIEGEL R: Clinical aspects of periarteritis nodosa, Arch. Int. Med., 1936, lviii, 993-1040. CrossrefGoogle Scholar33. WISE F: The relation of lupus erythematosus and tuberculosis, New York Med. Jr., 1918, cvii, 1164-1167. ZUMBUSCH, L. V.: Zur Ätiologie des Lupus Erythematodes, Arch. f. Dermat. u. Syph., 1925, cxlix, 136-141. Google Scholar34. KEEFERFELTY CSAR: Acute disseminate lupus erythematosus. Report of 3 fatal cases, Bull. Johns Hopkins Hosp., 1924, xxxv, 294-304. Google Scholar35. GOECKERMAN WH: Lupus erythematosus as a systemic disease, Jr. Am. Med. Assoc., 1923, lxxx, 542-547. CrossrefGoogle Scholar36. GENNERICH W: Ueber die Ätiologie des Lupus Erythematodes, Arch. f. Dermat. u. Syph., 1921, cxxxv, 184-207. CrossrefGoogle Scholar37. STOKES JN: The diagnosis of disseminate erythematous lupus, Med. Clin. North Am., 1926, x, 290-294. Google Scholar38. KEIL H: Relationship between lupus erythematosus and tuberculosis, Arch. Dermat. and Syph., 1933, xxviii, 765-779. CrossrefGoogle Scholar39. WISE F: The relation of lupus erythematosus and tuberculosis, New York Med. Jr., 1918, cvii, 1164-1167. ZUMBUSCH, L. V.: Zur Ätiologie des Lupus Erythematodes, Arch. f. Dermat. u. Syph., 1925, cxlix, 136-141. Google Scholar40. BAEHRSACKS GB: The occurrence of glomerulonephritis in association with verrucous endocarditis, Proc. New York Path. Soc., 1923, xxiii, 64-69. Google Scholar41. MANGESBAEHR MG: Periarteritis nodosa, Am. Jr. Med. Sci., 1921, clxii, 162-182. CrossrefGoogle Scholar42. VOLK R: Periarteritis nodosa bei einem Lupus Erythematodes Chronica cum Exacerbatione, Dermat. Ztschr., 1928, liii, 682-691. CrossrefGoogle Scholar43. BELOTERATNER GHHS: The so-called Libman-Sacks syndrome. Its relation to dermatology, Arch. Dermat. and Syph., 1936, xxxiii, 642-664. CrossrefGoogle Scholar44. HOLLANDERKASTLINFISHERSCHLESINGER LGJACR: Lupus erythematosus subacutus with an unusual blood picture. (A clinical study), Arch. Dermat. and Syph., 1932, xxv, 353-364. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bronx, New York*Received for publication February 21, 1938.†Case presented at meeting of Alumni of Lebanon Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByClinical effect of rituximab as early administration for refractory thrombotic thrombocytopenic purpura associated with connective tissue diseasesAnemia hemolítica microangiopática en lupus eritematoso sistémico: revisión narrativa de la literaturaParadigm shift of childhood thrombotic thrombocytopenic purpura with severe ADAMTS13 deficiencyRegistry of 919 Patients with Thrombotic Microangiopathies across Japan: Database of Nara Medical University during 1998-2008William Osler and development of the concept of systemic lupus erythematosusDescription of Systemic Lupus Erythematosus: A Historical PerspectiveThrombotic thrombocytopenic purpura in four siblingsThrombotic micro-angiopathy with macroscopic infarctionBIBLIOGRAPHYThrombotic thrombocytopenic purpura in siblingsThrombotic thrombocytopenic purpura with acute anuric renal failurePathology of the Cardiac Conduction System in Thrombotic Thrombocytopenic PurpuraTHOMAS N. JAMES, M.D., F.A.C.P., RAYMOND W. MONTO, M.D., F.A.C.P.Thrombotic thrombocytopenic purpura in pregnancyThrombotic thrombocytopenic purpuraPararheumatische Krankheiten (Sogenannte Kollagenkrankheiten)THROMBOTIC THROMBOCYTOPENIC PURPURA: REPORT OF A CASE AND REVIEW OF THE LITERATURE*J. W. KINGSLEY JR., M.D., REBECCA B. AQUINO, M.D.Thrombohemolytic thrombocytopenic purpuraTHROMBOTIC THROMBOCYTOPENIC PURPURA: A REVIEW OF THE LITERATURE WITH REPORT OF A CASE*EARL H. ANTESThrombotic thrombocytopenic purpuraTHROMBOHEMOLYTIC THROMBOCYTOPENIC PURPURA AND LUPUS ERYTHEMATOSUS*BERNARD M. SIEGEL, M.D., IRVING A. FRIEDMAN, M.D., SAMUEL KESSLER, M.D., STEVEN O. SCHWARTZ, M.D., F.A.C.P.Transient Hemolytic and Thrombocytopenic Episode (? Acute Transient Thrombohemolytic Thrombocytopenic Purpura), with Probable MeningococcemiaTHE ASSOCIATION OF THROMBOTIC THROMBOCYTOPENIC PURPURA AND DISSEMINATED LUPUS ERYTHEMATOSUS: REPORT OF A CASE*MAURICE H. LASZLO, M.D., ARTURO ALVAREZ, M.D., FREDERIC FELDMAN, M.D.Thrombotic thrombocytopenic purpuraThrombotic thrombocytopenic purpuraThrombotic thrombocytopenic purpuraThrombotic Thrombocytopenic PurpuraFebrile Thrombopenic Purpura with Hemolytic Anemia and Platelet ThrombosisDISSEMINATED LUPUS ERYTHEMATOSUS WITH PERICARDIAL EFFUSION*ARTHUR C. CURTIS, M.D., F.A.C.P., S. F. HORNE, M.D.THE NEUROPATHOLOGICAL ASPECTS OF THROMBOCYTIC ACROANGIOTHROMBOSIS: A CLINICO-ANATOMICAL STUDY OF GENERALIZED PLATELET THROMBOSISLupus erythematodes als allergisch-hyperergische Systemerkrankung 1 December 1939Volume 13, Issue 6Page: 1046-1067KeywordsAlumniArteriolesCapillariesEndocarditisLesionsLupus erythematosusThrombosis Issue Published: 1 December 1939 PDF DownloadLoading ...