Xenobiotica · 1984 · 13 citations · 5 references
MedicineNeurosciencePharmacologyClinical PharmacologyNeuropharmacologyPharmacodynamicsBlood-brain Barrier PenetrationBlood-brain Barrier PharmacologyDrug DispositionVasoactive MedicationsBeta-blocker UseCns PharmacodynamicsPharmacodynamics Of Neuroactive DrugsPhysicochemical PropertiesPropranolol TherapyRadioligand Pharmacodynamics
Whole-body autoradiography of rats dosed with [14C]propranolol or [14C]nadolol have confirmed physicochemical predictions that nadolol, in contrast to propranolol, penetrates the CNS only to a slight extent, if at all. Differences between the CNS penetration of different beta-blockers have implications for the mechanism of the hypotensive action and the prevalence of side-effects associated with disturbance of the CNS.
5
The Concept of a Blood-Brain Barrier
General Pharmacology The Vascular System · 1980 · 792 citations
Medicine, Neurosurgery, Pharmacology +16
β‐Adrenoceptor blockers and the blood‐brain barrier
G. Neil‐Dwyer, John D. Bartlett, J McAinsh et al. · British Journal of Clinical Pharmacology · 1981 · 225 citations · Full text
Medicine, Neurosurgery, Pharmacology +13