Decreased Serum Inhibin B/FSH Ratio as a Marker of Sertoli Cell Function in Male Survivors After Chemotherapy in Childhood and Adolescence

Abstract

These results show that the cytotoxic effects of CT cause severe damage to the germinal epithelium with subtle effects on Sertoli cells. To assess Sertoli cell function in men with primary testicular damage after treatment with CT in childhood and adolescence, the inhibin B level needs to be interpreted in the context of the circulating FSH, especially when normal FSH levels are observed.