Genetic Variations in the Sodium Balance-Regulating Genes <i>ENaC</i>, <i>NEDD4L</i>, <i>NDFIP2</i> and <i>USP2</i> Influence Blood Pressure and Hypertension

Abstract

These results support our hypothesis that individual variations in blood pressure are attributed to variants of the genes that regulate renal sodium reabsorption and excretion. Our data also suggest that it would be meaningful to investigate the role of NEDD4L-mediated ubiquitination in the pathogenesis of hypertension.