A Novel Three-Component One-Pot Pyrimidine Synthesis Based upon a Coupling−Isomerization Sequence

Abstract

[reaction: see text] 2,4,6-Tri(hetero)aryl-substituted pyrimidines can be readily synthesized in a three-component one-pot process based upon a coupling-isomerization sequence of an electron-poor (hetero)aryl halide and a terminal propargyl alcohol subsequently followed by a cyclocondensation with amidinium salts.