MLH1 and MSH2 protein immunohistochemistry is useful for detection of hereditary non‐polyposis colorectal cancer in young patients

Abstract

MLH1- or MSH2-deficient colorectal carcinomas of young patients exhibit pathological and molecular features similar to hereditary non-polyposis colorectal cancer. This suggests that MLH1 and MSH2 immunohistochemistry is valuable for detecting hereditary non-polyposis colorectal cancer in young patients.