Aspirin induces apoptosis in YD-8 human oral squamous carcinoma cells through activation of caspases, down-regulation of Mcl-1, and inactivation of ERK-1/2 and AKT

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

Yuri Lazebnik, Scott H. Kaufmann, Serge Desnoyers et al. · Nature · 1994 · 2.6K citations

Protein Chemistry, Biochemistry, Viral Polymerase Structure +6

X-linked IAP is a direct inhibitor of cell-death proteases

Quinn L. Deveraux, Ryōsuke Takahashi, Guy S. Salvesen et al. · Nature · 1997 · 1.9K citations

Protein Function, Apoptosis, Autophagy +5

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

Min-Jean Yin, Yumi Yamamoto, Richard B. Gaynor · Nature · 1998 · 1.6K citations

Inflammation, Cytokine, Anti-inflammatory +10

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

Sankar Ghosh, David Baltimore · Nature · 1990 · 1.2K citations

Inflammation, Cytokine, Inhibitor Iκb +11

Constitutive Activation of NF-κB during Progression of Breast Cancer to Hormone-Independent Growth

Harikrishna Nakshatri, Poornima Bhat‐Nakshatri, Daniel Martı́n et al. · Molecular and Cellular Biology · 1997 · 818 citations · Full text

Breast Oncology, Immunology, Transcription Factor Nf-kappab +20