Reduced Bone Mineral Density in SOCS-2-Deficient Mice

Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

Klara Sjögren, Jun‐Li Liu, K. Blad et al. · Proceedings of the National Academy of Sciences · 1999 · 954 citations

Life Sciences, Developmental Biology, Endocrinology +17

Circulating levels of IGF-1 directly regulate bone growth and density

Shoshana Yakar, Clifford J. Rosen, Wesley G. Beamer et al. · Journal of Clinical Investigation · 2002 · 846 citations · Full text

Medicine, Developmental Biology, Bone Metabolism +15

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

Warren S. Alexander, Robyn Starr, Jennifer E Fenner et al. · Cell · 1999 · 763 citations · Full text

Life Sciences, Cell Biology, Immunology +16

Interleukin‐6 deficient mice are protected from bone loss caused by estrogen depletion.

Valeria Poli, R. Balena, Elena Fattori et al. · The EMBO Journal · 1994 · 753 citations · Full text

Medicine, Endocrinology, Immunology +16

Circulating levels of IGF-1 directly regulate bone growth and density

Shoshana Yakar, Clifford J. Rosen, Wesley G. Beamer et al. · Journal of Clinical Investigation · 2002 · 727 citations

Medicine, Developmental Biology, Bone Metabolism +15