Staurosporine reduces P-glycoprotein expression and modulates multidrug resistance

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

Ulrich K. Laemmli · Nature · 1970 · 251.6K citations

Life Sciences, Microbiology, Molecular Biology +14

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

Takashi Tsuruo, Harumi Iida, Shigeru Tsukagoshi et al. · PubMed · 1981 · 1.5K citations

Medicine, Oncology, Pharmacology +7

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

Masayoshi Imagawa · Cell · 1987 · 1.4K citations

Life Sciences, Biochemistry, Molecular Biology +12

Expression of Multidrug Resistance Gene in Human Cancers

Lori J. Goldstein, Hanan Galski, Antonio Tito Fojo et al. · JNCI Journal of the National Cancer Institute · 1989 · 1.3K citations

Medicine, Cancer Biology, Oncology +11

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

Ira Pastan, Michael M. Gottesman, Kazumitsu Ueda et al. · Proceedings of the National Academy of Sciences · 1988 · 491 citations · Full text

Life Sciences, Microbiology, Pharmacology +11