Proton pump inhibitor responders who are not confirmed as <scp>GERD</scp> patients with impedance and pH monitoring: who are they?

Abstract

In a substantial subgroup of patients responding to PPI with typical reflux symptoms, the diagnosis of GERD cannot be confirmed with pH-impedance monitoring. Proton pump inhibitor response and presence of typical symptoms are thus not reliable predictors of the diagnosis and antireflux surgery should always be preceded by reflux monitoring.