Advanced Materials · 2014 · 436 citations · 32 references
MedicineOncologyRadiation OncologyDrug DeliveryMolecular OncologyRadiobiologyCancer NanomedicineNanomedicineRadiation TherapyRadiopharmaceutical DesignRadiopharmaceutical TherapyRadiopharmaceuticalsActive Tumor TargetingCancer NanotherapyGold NanostructuresPost InjectionRenal Clearance MechanismsTherapeutic RadiosensitizationTumor Targeting SpecificityTumor Uptake Kinetics
Radiosensitizers can increase local treatment efficacy under a relatively low and safe radiation dose, thereby facilitating tumor eradication and minimizing side effects. Here, a new class of radiosensitizers is reported, which contain several gold (Au) atoms embedded inside a peptide shell (e.g., Au10-12 (SG)10-12 ) and can achieve ultrahigh tumor uptake (10.86 SUV at 24 h post injection) and targeting specificity, efficient renal clearance, and high radiotherapy enhancement.
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Ahmedin Jemal, Freddie Bray, Jacques Ferlay et al. · CA A Cancer Journal for Clinicians · 2011 · 55K citations · Full text
In vivo cancer targeting and imaging with semiconductor quantum dots
Xiaohu Gao, Yuanyuan Cui, Richard M. Levenson et al. · Nature Biotechnology · 2004 · 4.7K citations
Renal clearance of quantum dots
Hak Soo Choi, Wenhao Liu, Preeti Misra et al. · Nature Biotechnology · 2007 · 4.4K citations · Full text