Effect of <scp>M</scp>as‐related gene (<scp>Mrg</scp>) receptors on hyperalgesia in rats with <scp>CFA</scp>‐induced inflammation via direct and indirect mechanisms

Abstract

Activation of MrgC receptors suppressed up-regulation of pronociceptive mediators and consequently inhibited inflammatory pain, because of the activation of up-regulated MrgC receptors and subsequent endogenous activity at MORs. The uniquely distributed MrgC receptors could be a novel target for relieving inflammatory pain.