Fatty Acid Binding Protein Deletion Suppresses Inflammatory Pain through Endocannabinoid/<i>N</i>-Acylethanolamine-Dependent Mechanisms

Abstract

This study demonstrates that mice lacking FABPs possess elevated levels of N-acylethanolamines, consistent with the idea that FABPs regulate the endocannabinoid and N-acylethanolamine tone in vivo. The antinociceptive effects observed in the knockout mice support a role for FABPs in regulating nociception and suggest that these proteins should serve as targets for the development of future analgesics.