Response Inhibition and Reward Response Bias Mediate the Predictive Relationships Between Impulsivity and Sensation Seeking and Common and Unique Variance in Conduct Disorder and Substance Misuse

Abstract

Findings show a dissociation between inhibitory measures associated with CD symptoms and those associated with binge drinking, with "cool" inhibitory and executive functions being associated with CD but "hot," reward-related disinhibition measures being specific mediators between SS and binge drinking. The findings support the theoretical conceptualization for dual cognitive/motivational pathways of disinhibition, in this case IMP and SS, and their unique association with externalizing behavior in adolescence.