Palladium‐Mediated [¹¹C]Carbonylation at Atmospheric Pressure: A General Method Using Xantphos as Supporting Ligand

Abstract

Abstract The palladium‐catalyzed [ 11 C]carbonylation of aryl halides and triflates was achieved at atmospheric pressure by employing xantphos as the supporting ligand. Aryl halides were converted into their corresponding [ 11 C]amides in good to excellent yields. The conditions were also successfully employed in the radiolabeling of an [ 11 C]ester, a [ 11 C]carboxylic acid, an [ 11 C]aldehyde, and a [ 11 C]ketone.