Cousins, siblings, or copies: the genomics of recurrent <i>Staphylococcus aureus</i> infections in chronic rhinosinusitis

Abstract

The same S. aureus strain appears to persist in the paranasal sinuses of CRS patients despite multiple courses of culture-directed antibiotics. This suggests that conventional antimicrobial therapies in patients with CRS may not eliminate the organism. This may be partly explained by the formation of biofilms in the paranasal sinus region.