Intra‐Intermolecular Palladium‐Catalyzed Domino Reactions of Glycine Allylamides for the Synthesis of Diversely Functionalized Piperazinones

Abstract

Abstract Easily accessible N ‐tosylglycine allylamides have been converted into diversely functionalized piperazinone derivatives by inter‐intramolecular oxidative domino palladium‐catalyzed reactions. Aminochlorination and aminoacetoxylation processes were achieved by employing CuCl 2 and PhI(OAc) 2 as the oxidizing agents to give 5‐chloromethyl‐ and 5‐acetoxymethyl‐substituted piperazinones, respectively.