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The effects of selected cholinergic drugs and strychine on cochlear responses and olivo-cochlear inhibition.
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1969
Year
Cholinergic DrugsIntraarterial CholineAnesthetic MechanismPharmacotherapyExperimental PharmacologyOlivo-cochlear InhibitionN1 DepressionAuditory ScienceAnesthetic PharmacologyHealth SciencesAnimal PhysiologyO-c Bundle StimulationAudiologyAuditory ResearchNervous SystemPharmacologyAuditory Hair CellsHearing LossAnaesthetic AgentCochlear ResponsesNeurophysiologyPhysiologyAuditory PhysiologyCochlear PhysiologyNeuroscienceCentral Nervous SystemAnesthesiaMedicineAuditory SystemAnesthesiology
The pharmacology of olivo-cochlear (o-c) inhibition was investigated in cats anesthetized with Dial-urethane and paralyzed with gallarnine. Intravenous strychnine blocked the N1 depression produced by i.a. acetylcholine as well as the effects produced by o-c bundle stimulation. Intraarterial hemicholinium (Schueler9s HC-3) produced a partial block of o-c bundle stimulation effects. Intraarterial choline produced N1 depression in control animals and animals which had received HC-3 and a complete block of o-c bundle stimulation effects in the HC-3 animals. Thus, the cochlear action of HC-3 appeared to be similar to its action at the neuromuscular junction. Intraarterial physostigrnine, atropine, gallamine and mecamylamine produced no significant changes in either control N1 and microphonics or in the o-c bundle stimulation effects. it is concluded that a definitive evaluation of the pharmacology of olivo-cochlear inhibition cannot be made at this time.