The Tranylcypromine Isomers : A Controlled Clinical Trial

Abstract

The plus (+ ) and minus (–) isomers of tranylcypromine (Parnate) were tested under double-blind conditions on 11 depressed patients. The (—) isomer was the more effective and produced fewer side effects. Because the (–) isomer has been shown to be a stronger blocker of the reuptake mechanism for brain amines and a weaker inhibitor of monoamine oxidase than the (+) isomer, the results obtained here are of particular interest.