The expression of p53, p16 proteins and prevalence of apoptosis in oral squamous cell carcinoma. Correlation with mode of invasion grading system.

Abstract

The present findings revealed that p53 mutations alone, may play a role in pathogenesis of lip cancers but not in intra OSCC. P16 may have a greater role in the development of intra OSCC. P53 positivity and low AI value may be a predictor of poor prognosis in OSCC.