A <scp>V</scp>740<scp>L</scp> mutation in glycoprotein <scp>IIb</scp> defines a novel epitope (<scp>W</scp>ar) associated with fetomaternal alloimmune thrombocytopenia

Abstract

The V740L polymorphism defines a new low-frequency antigen implicated in two cases of FMAIT in a single family. Low-frequency HPAs are clinically important and their elucidation requires both crossmatch studies and gene sequencing in cases where there is strong clinical evidence of FMAIT but initial laboratory investigations do not support the diagnosis.