Journal of Clinical Microbiology · 1987 · 105 citations · 8 references
Veterinary MedicineInfectious DiseasesMicrobiologyDiagnostic MicrobiologyMedical MicrobiologyVirologyInfectious Disease DetectionRespiratory InfectionsRespiratory Infectious DiseasesRespiratory Tract InfectionsViral DiagnosticsViral InfectionsRapid Detection AssaysRapid Viral DiagnosticsRelative EfficiencyRespiratory Syncytial Virus DiagnosticsRespiratory Viral InfectionsRespiratory VirusesSelective Reduction DecisionsViral Respiratory Infections
Rapid immunofluorescence (FA) methods for the detection of common respiratory viruses were compared with culture results over a 3-year period to assess the relative efficiency of FA in a clinical laboratory setting. For respiratory syncytial virus, efficiencies were high (sensitivity, 90 to 95%; specificity, 92 to 95%). The sensitivity of FA for detection of parainfluenza virus type 1, parainfluenza virus type 3, influenza A virus, and adenoviruses ranged from 28 to 63%, but specificities for these viruses were uniformly 98 to 100%. The observations form a basis for consideration of selective reduction of routine culture procedures for specimens with initial positive rapid FA results; however, the possibility of dual viral infection in some situations must also be considered.
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