Publication | Closed Access
Catalyst-free dehydrative S<sub>N</sub>1-type reaction of indolyl alcohols with diverse nucleophiles “on water”
119
Citations
53
References
2015
Year
Diverse NucleophilesChemical EngineeringVersatile 3-Indolyl DerivativesEngineeringAlcohol DehydrogenasesNatural SciencesDiversity-oriented SynthesisOrganic ChemistryCatalysisSynthetic ChemistryChemistryHomogeneous CatalysisMolecular CatalysisNatural Product SynthesisIndolyl AlcoholsIndolyl CompoundsBiomolecular EngineeringWater ”
An efficient dehydrative S<sub>N</sub>1-type reaction of indolyl alcohols with diverse nucleophiles was developed using water as the solvent, affording versatile 3-indolyl derivatives in high yields. The advantages of being catalyst-free, environmentally benign, and wide substrate scope make it a promising method for preparation of indolyl compounds.
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