Evaluation of high-dose daptomycin for therapy of experimental Staphylococcus aureus foreign body infection

Abstract

The improved efficacy of the twice-daily regimen of daptomycin (30 mg/kg) compared to oxacillin (200 mg/kg) or vancomycin (50 mg/kg) may result from optimisation of its pharmacokinetic and bactericidal properties in infected cage fluids.