Attenuation of N‐nitrosodiethylamine‐induced liver fibrosis by high‐molecular‐weight fucoidan derived from <i>Cladosiphon okamuranus</i>

Abstract

These findings suggest that the HMW fucoidan treatment causes anti-fibrogenesis in DEN-induced liver cirrhosis through the downregulation of transforming growth factor beta 1 and chemokine ligand 12 expressions, and that scavenging lipid peroxidation is well-incorporated in the liver.