Molecules · 2015 · 27 citations · 30 references
Antiparasitic AgentPharmacotherapyPharmaceutical ChemistryDrug ResistanceMedicinal ChemistryMao-a Inhibition ActivityStandard ClorgylineInhibitory ActivityBiochemistryMechanism Of ActionPharmacological AgentTheir Mao InhibitorsDrug DevelopmentPharmacologyAmino Acid DerivativesPreliminary Biological EvaluationNatural SciencesMedicineDrug Discovery1,3,5-Triazine Amino Acid
Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to that of the standard clorgyline, with apparently more selective inhibitory activity toward MAO-A than MAO-B and no significant acute toxicity.
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Monoamine oxidase inhibitors and the cheese effect
Mary C. Anderson, F Hasan, John M. McCrodden et al. · Neurochemical Research · 1993 · 158 citations
Psychoactive Drug, Monoamine Oxidase Inhibitors, Biochemistry +4
Burkhard Klenke, Mhairi Stewart, Michael P. Barrett et al. · Journal of Medicinal Chemistry · 2001 · 137 citations · Full text
Medicinal Chemistry, Bioorganic Chemistry, Melamine Analogues +15