Acid‐Catalyzed Synthesis of α‐Trifluoromethylthiolated Carbonyl Compounds

Abstract

Abstract The α‐trifluoromethylthiolation of carbonyl compounds in soft acidic conditions has been developed. With this method only mono‐trifluoromethylthiolation was selectively observed. Base‐sensitive ketones can then be trifluoromethylthiolated. More sensitive aldehydes are also trifluoromethylthiolated under these conditions with good yields. This work provides a new route towards the synthesis of various valuable trifluoromethylthiolated molecules.