Radical fluorination powered expedient synthesis of 3-fluorobicyclo[1.1.1]pentan-1-amine

Abstract

Exploration of novel chemical space, a modern trend in medicinal chemistry, is heavily reliant on synthetic access to new and interesting building blocks. In this direction, the following work describes an expedient synthesis of one such moiety, 3-fluorobicyclo[1.1.1]pentan-1-amine, by employing radical fluorination.