Publication | Closed Access
The most electron-donating sites in duplex DNA: guanine-guanine stacking rule.
14
Citations
0
References
1995
Year
B DnaDnaDna AnalysisMolecular BiologyCt InteractionsGuanine-guanine Stacking RuleDna NanotechnologyNucleic Acid ChemistryDna ComputingBiophysicsBiochemistryOligonucleotideDna ReplicationStructural BiologyChromatinNatural SciencesNucleic Acid BiochemistryG-g Stacking RuleMolecular BiophysicsMedicine
The most readily oxidizable sites in one-electron oxidation of duplex DNA are shown to be the guanine (G) residues located 5' to guanine. Based on experimental results and ab initio calculations, G-G stacking rule has been proposed. This rule indicates the most electron-rich sites contained in B DNA and is very useful for understanding CT interactions between electron-accepting molecules and DNA.