Experimental Radiation Synovectomy by ¹⁶⁵Dy Ferric Hydroxide Macroaggregate

Abstract

Abstract The short half—life beta emitter 165 Dy coprecipitated as a macroaggregate with ferric hydroxide (FHMA) has been shown to destroy knee synovium in the antigen—induced arthritic rabbit. Using 153 Gd as a gamma tracer for leakage studies revealed that the leakage of this system from rabbit knee joints never exceeded 1.2% over 24 hours. This is much less than the leakage rates reported from any human studies or our rabbit studies using 198 Au.