Targeted induction of endogenous <i>NKX3‐1</i> by small activating RNA inhibits prostate tumor growth

Abstract

By revealing several important target genes of NKX3-1, our findings corroborated NKX3-1's role as a tumor suppressor gene through direct regulation of the cell cycle and growth/survival pathways. This study also validated the therapeutic potential of saRNA for the treatment of prostate cancer via targeted activation of tumor suppressor genes.