Associations among <i>IRS1</i>, <i>IRS2</i>, <i>IGF1</i>, and <i>IGFBP3</i> Genetic Polymorphisms and Colorectal Cancer

Abstract

Both IRS1 and IRS2 variants were associated with colon cancer risk independently. Associations were slightly stronger when polymorphisms in multiple genes were evaluated in conjunction with other genes rather than individually. These data suggest that the insulin-related pathway may be important in the etiology of colon cancer but not rectal cancer.