Uses of multiagents systems for simulation of MAPK pathway

Abstract

Since emergence of molecular biology, one has improved knowledge about intracellular networks controlling cell behavior. In parallel, advances in mathematic and computer science allow one to simulate such complex phenomena. Moreover, most methods need a global resolution of the system which makes it difficult to be created and modified. We proposed, in this study, a distributed approach by multiagent system (MAS), to simulate the MAPK pathway. Our results show that such simulation is possible and allows "in virtuo" experimentation, i.e. model perturbation during its execution.