Plasma-Activated Polypropylene Mesh-Gelatin Scaffold Composite as Potential Implant for Bioactive Hernia Treatment

Abstract

Novel, polypropylene mesh (PPmesh) – gelatin scaffold (GELscaffold) composites are prepared from O2-plasma activated PPmesh, coated with GEL solution being in-situ structured in a 3D scaffold with by-preparation tuned, gradual porosity. The fabricated biomimetic-like composites demonstrate frequency-dependent rheological behaviour and high (up to 100%) intrinsic and/or by ϵ-poly-L-lysine evoked antibacterial activity against S. aureus and E. coli, latter demonstrating preparation-dependant releasing profile, without triggering in-vitro cytotoxicity. Finally, long-term (up to 2 months) biodegradation resistance highlight the composite potential as active, biomimetic barrier in hernia treatment.