Identifying 24 h variation in the pharmacokinetics of levofloxacin: a population pharmacokinetic approach

Abstract

The finding that the absorption rate constant showed considerable 24 h variation may be relevant for drugs with similar physicochemical properties as levofloxacin that have a narrower therapeutic index. Levofloxacin, however, can be dosed without taking into account the time of day, at least in terms of its pharmacokinetics.