Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using<scp>PKPD</scp>modelling

Abstract

A systems pharmacology model characterizing the interrelationship between MAP, CO, HR, SV and TPR was obtained in hypertensive and normotensive rats. This extended model can quantify dynamic changes in the CVS and elucidate the MoA for novel compounds, with one site of action, using only HR and MAP measurements. Whether the model can be applied for compounds with a more complex MoA remains to be established.