Influence of the drug exposure definition on the assessment of the antipsychotic metabolic impact in patients initially treated with mood‐stabilizers

Abstract

The definition of exposure to antipsychotics in epidemiological studies exploring their metabolic impact is of paramount importance in understanding this association. Different definitions can lead to opposite and seemingly nonsensical results. Not taking into account past exposure, in order to minimize the depletion of susceptible effects, may lead to absurd results.