Presynaptic adenosine <scp>A_2A</scp> receptors dampen cannabinoid <scp>CB</scp>₁ receptor‐mediated inhibition of corticostriatal glutamatergic transmission

Abstract

Activation of presynaptic A2A receptors dampened CB1 receptor-mediated inhibition of corticostriatal terminals. This constitutes a thus far unrecognized mechanism to modulate the potent CB1 receptor-mediated presynaptic inhibition, allowing frequency-dependent enhancement of synaptic efficacy at corticostriatal synapses.