PubMed · 1978 · 102 citations · 0 references
Life SciencesImmunologyMicrobiologyHypersensitivityImmunology Of Infectious DiseasesMucosal ImmunologyAdaptive Immune ResponsesCell-mediated ImmunityCellular Immune ResponsesFungal ImmunologyImmune Responses To InfectionOral CandidiasisCandida Albicans InfectionCandida ImmunologyCandida-host InteractionsCutaneous CandidiasisDelayed Cutaneous HypersensitivityDelayed Hypersensitivity ReactionsFungal Infection ImmunityHost Immune Response To Candida
Passive transfer of immune serum gave a significant degree of protection against deep seated candidiasis in mice. Repeated attempts to transfer resistance by the transfer of sensitized lymphoid cells gave negative results, even though cutaneous delayed hypersensitivity was transferred by the cells. The results suggest that cell-mediated immunity is not of primary importance in this model of murine candidiasis, and that humoral immunity contributes to protection.