The Journal of Immunology · 1964 · 10 citations · 0 references
Life SciencesImmunologySurgeryDermatologic SurgeryTransplant ImmunologyTransplant SurgeryAcute RejectionAllograft RejectionAntibody-mediated RejectionGraft RejectionSkin GraftingTransplant RejectionAllogeneic Skin GraftsAllograft Rejection MechanismsGuinea Pig ModelsSkin Grafts
Summary The effects of a partially purified transfer factor (PTF) on specific guinea pig skin homografts has been described. There is a significant increase in the rate of rejection of such grafts, compared with controls. PTF taken from nonspecifically stimulated animals is inactive, as is that prepared from second-set recipients. There is no obvious correlation between the size of the cutaneous transfer reaction and the anti-graft activity of these preparations.