Behavioral Deficits and Striatal DA Signaling in LRRK2 p.G2019S Transgenic Rats: A Multimodal Investigation Including PET Neuroimaging - Concepedia

Concepedia

Publication | Closed Access

Behavioral Deficits and Striatal DA Signaling in LRRK2 p.G2019S Transgenic Rats: A Multimodal Investigation Including PET Neuroimaging

36

Citations

0

References

2014

Year

Matthew Walker, Mattia Volta, Stefano Cataldi, Katherine Dinelle, Dayne Beccano-Kelly, Lise N. Munsie, Rick Kornelsen, C.J. Mah, Patrick Chou, Kimberley Co,

Journal of Parkinson s Disease

Abstract

Neuroimaging using dopaminergic PET did not recapitulate prior studies in human LRRK2 mutation carriers. Consistently, LRRK2 p.G2019S rats do not develop overt neurodegeneration; however, they do exhibit behavioral abnormalities.