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RENAL HISTOLOGY DURING TREATMENT WITH OXAZOLIDINE-DIONES (TRIMETHADIONE, ETHADIONE, AND PARAMETHADIONE)
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1962
Year
Glomerular DiseaseAnd ParamethadioneRenal PathologyGlomerulonephritisRenal FunctionElectron MicroscopyIga GlomerulonephritisAcute Kidney InjuryChronic Kidney DiseaseRenal PharmacologyHemodialysisUrological ResearchKidney FailureNephrotic SyndromeRenal PathophysiologyPharmacologyUrologyRenal DiseasePetit Mal SeizuresMedicineNephrologyKidney Research
Seven patients with petit mal seizures treated with trimethadione, ethadione, or paramethadione for long periods were subjected to renal biopsy at the age of 14½ 16½ years. None of the patients had clinical signs of renal disease at the time of the biopsy, but three of them had previously shown transient hematuria or proteinuria. The renal histology was studied by conventional methods and by electron microscopy, the latter method only including the glomeruli. The changes found must with the present knowledge be regarded as physiological. A short report is given of a patient with phenylketonuria and epilepsy who developed a nephrotic syndrome during treatment with tridione. No definite pathologic renal changes were demonstrated at the when the clinical symptoms had disappeared.