Effect of Vincaleukoblastine on metastatic choriocarcinoma and related trophoblastic tumors in women.

Abstract

An alkaloid, Vincaleukoblastine, has suppressed tumor growth and activity in five of eight women with methotrexate-resistant, metastatic trophoblastic disease. In three of these patients the urinary gonadotropin excretion reached normal levels, and in two other patients there was a decrease in pulmonary metastases. Reversible toxic effects have included bone marrow depression with severe leukopenia, alopecia, and neurotoxicity.