Language-related field potentials in the anterior-medial temporal lobe: I. Intracranial distribution and neural generators

TLDR

Intracranial electrodes recorded field potentials while subjects viewed word‑by‑word sentences, with half ending normally and half with a semantically anomalous word. Anomalous sentence endings produced a large negative field potential peaking near 400 ms in the anterior medial temporal lobe, with a complementary positive potential in subdural electrodes near the collateral sulcus, indicating a neocortical generator near the collateral sulcus and anterior fusiform gyrus and resembling the scalp N400 associated with semantic processing.

Abstract

Field potentials were recorded from intracranial electrodes in humans to study language-related processing. Subjects viewed sentences in which each word was presented successively in the center of a video monitor. Half of the sentences ended normally, while the other half ended with a semantically anomalous word. The anomalous sentence-ending words elicited a large negative field potential with a peak latency near 400 msec, which was focally distributed bilaterally in the anterior medial temporal lobe (AMTL), anterior to the hippocampus and near the amygdala. Subdural electrodes positioned near the collateral sulcus just inferior and lateral to the amygdala recorded a positive field potential at the same latency. This spatial distribution of voltage suggested that this language-sensitive field potential was generated in the neocortex near the collateral sulcus and anterior fusiform gyrus. Additional task-related field potentials were recorded in the hippocampus. The AMTL field potential at 400 msec shares characteristics with the N400 potential recorded from scalp electrodes that has been associated with semantic processing.