Short-Term Immunogenicity and Safety of an Accelerated Pre-Exposure Prophylaxis Regimen with Japanese Encephalitis Vaccine in Combination with a Rabies Vaccine: a Phase Iii, Multicenter, Observer-Blind Study

Abstract

This was the first randomized, controlled trial that demonstrated the strong short-term immunogenicity of a new, accelerated, 1-week JE-regimen, which was noninferior to that of the standard regimen, with a satisfactory tolerability and safety profile and no impact of concomitant rabies vaccination. This accelerated regimen, if licensed, could potentially be a valid alternative for individuals requiring a primary series of JE vaccination and rabies pre-exposure prophylaxis on short notice.