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The effects of 2-acetylaminofluorene and nitrite on free radicals and carcinogenesis in rat liver.
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1970
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Signal-bearing ComplexAnticarcinogenic ActivityToxicological MechanismOxidative StressFree RadicalsToxicologyHepatotoxicityToxicological AspectRadiation OncologyHealth SciencesBiochemistryVarious Chemical CarcinogensLiver PhysiologyNeuropharmacologyMetabolomicsExperimental ToxicologyPharmacologyDrug-induced Liver InjuryRat LiverMedicineNitrosative Stress
The intensity of the abnormal electron spin resonance signal previously observed in the livers of rats which were fed various chemical carcinogens is found to depend on the intake of the carcinogen, protein, and nitrate or nitrite. Nitrite enhances the intensity of the abnormal electron spin resonance signal and inhibits the carcinogenicity of 2-acetyl-aminofluorene. The appearance of the signal-bearing complex and the possible mechanism of its anticarcinogenic activity are discussed.