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Effect of Calcium Chromate Dust, Influenza Virus, and 100 R Whole-Body X Radiation on Lung Tumor Incidence in Mice<xref ref-type="fn" rid="FN1">2</xref>
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1971
Year
Inflammatory Lung DiseaseLung InflammationTumor IncidenceRadiation EffectRadiation ExposurePathologyPulmonary Alveolar ProteinosisRadiation BiologyCalcium Chromate DustRadiation MedicineRespiratory ToxicologyRadiation OncologyCancer ResearchAllergyRadiation TherapyEnvironmental Lung DiseasesLymphoma IncidencePulmonary FibrosisInfluenza VirusRadiation EffectsLung CancerPulmonary DiseaseInhalation ToxicologyLung Tumor IncidenceChronic Inhalation ExposureMedicine
Chronic inhalation exposure of C57BL/6 mice to calcium chromate(CaCrO4) dustresultedin a fourfold increasein pulmonary adenoma incidence. Acute exposure to 100 R whole-body X radiation caused a similar increase in tumor incidence. The effects of the two tumorigenic insults were not additive. PRe influenza virus infection suppressed spontaneous as well as X ray- and CaCrO4-induced pulmonary adenoma development. The overall lung adenoma incidence was higher in males than in females. CaCrO4 also induced other pathological changes in the respiratory tract, such as epithelial necrosis and regenerative hyperplasia in the conducting airways, alveolar “bronchiolization,” alveolar proteinosis, and emphysema-like changes, and suppressed the lymphoma incidence.