Killing of Blood-Stage Murine Malaria Parasites by Hydrogen Peroxide

Abstract

Both nonlethal Plasmodium yoelii and lethal Plasmodium berghei were killed in vitro by hydrogen peroxide at concentrations as low as 10(-5) M. Higher concentrations were required in the presence of added normal erythrocytes. Injection of hydrogen peroxide in vivo significantly reduced P. yoelii parasitemia but had less effect on P. berghei.